Cume means 'heart, soul' in Timucua and areco means 'make'. The combination of the two quasi-idiomatically means 'understand', and this is a frequent beginning of the confessional material, in the form 'you must understand X'. This is expressed in a few ways, but one of the most common is
cume areco-no le-habe
heart make-nmzr be-irr
'Understanding will be' = 'You must understand'.
Some textual examples:
'You must understand, this evil person that I explained to you previously, Lucifer, the hiti as you say'
'You must understand this, due to Adam and Eve, the heavens, as I previously said to you, are closed...'
